St. Louis Hotzone

The St. Louis Hotzone is an area in the city of St. Louis, Missouri, seen in Prime Video's. It is an epicenter of a supposed flu outbreak and only those with direct authorization from the United States federal government are allowed to enter. It is guarded by members of the United States Army, such as PFC Betsy Ruskin.

Dr. Michael Stearns, a scientist who discovered a vaccine and cure for the flu, tries to bluff his way into the hotzone, determined to prove that it works. He claims to have authorization from the head of the CDC herself, but when Ruskin calls his bluff, he is forced to come up with another plan. He later manages to gain entry along with Dale Warwick, supposedly a fellow a scientist whose daughter Charlotte is inside, infected with the flu. Unknown to Stearns, the entire thing is a ploy, designed to trick Stearns in riling up public support to fast-track an emergency use authorization for the flu vaccine. This is part of a plot by a group called the Harvest and Dr. Kevin Christie to use the vaccine as a vector for a virus called the Undoing which is intended to sterilize people, ending the problem of overpopulation.